Sedating ssri

Diphenidol (Vontrol), is also an anticholinergic, although little used in the US.

There are also some reports of scopolamine inducing migraine, as well as a withdrawall syndrome.

Table 1 lists commonly used vestibular suppressants, which consist of three major drug groups, the anticholinergics, the antihistamines, and the benzodiazepines.

There are differential effects across benzodiazepines on Gaba-A receptor subtypes. Addiction, impaired memory, increased risk of falling, and possibly impaired vestibular compensation are their main shortcomings.

Lorazepam and klonazepam are particularly useful agents because of their effectiveness and simple kinetics.

We also highly recommend the neuropharmacology review article written by Soto et al (2013).

A discussion of drug treatment should start with a discussion of the neurotransmitters used to signal in the vestibular system. Vestibular suppressant and antiemetic drugs are the mainstay of treatment of vertigo.

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